Which term describes several conditions characterized by formation of platelet-fibrin thrombi in small vessels leading to small vessel occlusion and a consumptive coagulopathy?

Which term describes several conditions characterized by formation of platelet-fibrin thrombi in small vessels leading to small vessel occlusion and a consumptive coagulopathy?

• A. DIC
• B. TTP
• C. HUS
• D. Thrombotic microangiopathic purpura

Answer: (D)

Widespread activation of coagulation with formation of platelet-fibrin thrombi in the microvasculature leads to small-vessel occlusion and consumption of platelets and coagulation factors, producing a consumptive coagulopathy. The term that captures this scenario across conditions is disseminated intravascular coagulation. It differs from thrombotic microangiopathy (the umbrella concept for TTP and HUS), where microthrombi form in small vessels but the coagulation tests are not characteristically consumed; DIC typically shows abnormal coagulation studies (prolonged PT/aPTT, low fibrinogen, elevated D-dimer) due to systemic consumption.

Widespread activation of coagulation with formation of platelet-fibrin thrombi in the microvasculature leads to small-vessel occlusion and consumption of platelets and coagulation factors, producing a consumptive coagulopathy. The term that captures this scenario across conditions is disseminated intravascular coagulation. It differs from thrombotic microangiopathy (the umbrella concept for TTP and HUS), where microthrombi form in small vessels but the coagulation tests are not characteristically consumed; DIC typically shows abnormal coagulation studies (prolonged PT/aPTT, low fibrinogen, elevated D-dimer) due to systemic consumption.