Transplant-associated Kaposi sarcoma typically presents in which setting?

Transplant-associated Kaposi sarcoma typically presents in which setting?

• A. AIDS-associated KS
• B. Transplant-associated KS
• C. Classic KS
• D. Endemic KS

Answer: (B)

Transplant-associated KS is the iatrogenic form that occurs in solid organ transplant recipients who are on chronic immunosuppressive therapy. Immunosuppression allows HHV-8–driven endothelial cells to proliferate, producing violaceous skin lesions that may also involve mucosa or internal organs. It typically appears after transplantation, often months to years later, and can improve if immunosuppression is reduced or switched to agents like sirolimus, which may have anti-KS effects. This setting distinguishes it from AIDS-associated KS, classic KS, and endemic KS, which arise in the contexts of HIV infection, geographic/age patterns, or endemic HHV-8 exposure, respectively.

Transplant-associated KS is the iatrogenic form that occurs in solid organ transplant recipients who are on chronic immunosuppressive therapy. Immunosuppression allows HHV-8–driven endothelial cells to proliferate, producing violaceous skin lesions that may also involve mucosa or internal organs. It typically appears after transplantation, often months to years later, and can improve if immunosuppression is reduced or switched to agents like sirolimus, which may have anti-KS effects. This setting distinguishes it from AIDS-associated KS, classic KS, and endemic KS, which arise in the contexts of HIV infection, geographic/age patterns, or endemic HHV-8 exposure, respectively.