Most common form of thalassemia?

Most common form of thalassemia?

• A. B-thalassemia
• B. Alpha-thalassemia
• C. Delta-thalassemia
• D. Gamma-thalassemia

Answer: (A)

Thalassemias are disorders from impaired production of one of the globin chains. The most common form worldwide is beta-thalassemia, because mutations affecting beta-globin production are the most frequent cause of clinically significant disease. When beta-globin synthesis is reduced, excess alpha chains cause ineffective erythropoiesis and hemolysis, leading to microcytic, hypochromic anemia. Diagnostic clues include elevated HbA2 and HbF levels. While alpha-, delta-, and gamma-thalassemias occur in various populations, none are as prevalent overall as beta-thalassemia.

Thalassemias are disorders from impaired production of one of the globin chains. The most common form worldwide is beta-thalassemia, because mutations affecting beta-globin production are the most frequent cause of clinically significant disease. When beta-globin synthesis is reduced, excess alpha chains cause ineffective erythropoiesis and hemolysis, leading to microcytic, hypochromic anemia. Diagnostic clues include elevated HbA2 and HbF levels. While alpha-, delta-, and gamma-thalassemias occur in various populations, none are as prevalent overall as beta-thalassemia.