Liver lesions in angiosarcoma are associated with which exposure?

Liver lesions in angiosarcoma are associated with which exposure?

• A. Lead
• B. Mercury
• C. Cadmium
• D. Arsenic

Answer: (D)

Hepatic angiosarcoma has strong ties to certain chemical exposures that cause malignant transformation of liver blood vessel lining cells. Among common toxic metals, arsenic stands out as a known carcinogen linked to angiosarcoma of the liver. Chronic arsenic exposure—historically from contaminated water, mining, pesticides, and other industrial sources—can drive DNA damage and genomic instability in endothelial cells, promoting the development of angiosarcoma in the liver. Lead, mercury, and cadmium are toxic in various contexts, but they are not classically associated with hepatic angiosarcoma. Therefore, arsenic is the best-supported exposure linked to liver angiosarcoma.

Hepatic angiosarcoma has strong ties to certain chemical exposures that cause malignant transformation of liver blood vessel lining cells. Among common toxic metals, arsenic stands out as a known carcinogen linked to angiosarcoma of the liver. Chronic arsenic exposure—historically from contaminated water, mining, pesticides, and other industrial sources—can drive DNA damage and genomic instability in endothelial cells, promoting the development of angiosarcoma in the liver.

Lead, mercury, and cadmium are toxic in various contexts, but they are not classically associated with hepatic angiosarcoma. Therefore, arsenic is the best-supported exposure linked to liver angiosarcoma.