In PAN, inflammatory process can lead to what vascular complication that may rupture?

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Multiple Choice

In PAN, inflammatory process can lead to what vascular complication that may rupture?

Explanation:
In PAN, the inflammatory process causes transmural, necrotizing inflammation of medium-sized arteries with fibrinoid necrosis. This destroys and weakens the vessel wall, leading to the formation of aneurysms. Because these aneurysms are fragile, they may rupture and cause hemorrhage in affected organs (such as the kidneys or gut). Fibrosis or calcifications aren’t the acute rupture risk, and while thrombosis can occur, the rupture-prone complication due to wall destruction is aneurysm formation.

In PAN, the inflammatory process causes transmural, necrotizing inflammation of medium-sized arteries with fibrinoid necrosis. This destroys and weakens the vessel wall, leading to the formation of aneurysms. Because these aneurysms are fragile, they may rupture and cause hemorrhage in affected organs (such as the kidneys or gut). Fibrosis or calcifications aren’t the acute rupture risk, and while thrombosis can occur, the rupture-prone complication due to wall destruction is aneurysm formation.

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