Hemophilia A and von Willebrand disease are examples of which category?

Hemophilia A and von Willebrand disease are examples of which category?

• A. Autoimmune bleeding disorders
• B. Acquired coagulation disorders
• C. Congenital clotting factor deficiencies
• D. Platelet disorders

Answer: (C)

These are inherited bleeding disorders due to lack or dysfunction of proteins essential for hemostasis. Hemophilia A is a deficiency of factor VIII. Von Willebrand disease is a deficiency or dysfunction of von Willebrand factor, which is needed for platelet adhesion and also stabilizes factor VIII. Because both conditions are present from birth and involve deficiencies of proteins that drive clot formation, they fit best under congenital clotting factor deficiencies. They are not autoimmune or acquired, and while von Willebrand disease affects platelets, the underlying issue is a congenital plasma protein deficiency/dysfunction rather than a primary platelet disorder.

These are inherited bleeding disorders due to lack or dysfunction of proteins essential for hemostasis. Hemophilia A is a deficiency of factor VIII. Von Willebrand disease is a deficiency or dysfunction of von Willebrand factor, which is needed for platelet adhesion and also stabilizes factor VIII. Because both conditions are present from birth and involve deficiencies of proteins that drive clot formation, they fit best under congenital clotting factor deficiencies. They are not autoimmune or acquired, and while von Willebrand disease affects platelets, the underlying issue is a congenital plasma protein deficiency/dysfunction rather than a primary platelet disorder.