Fibromuscular dysplasia has ____________ and ___________ of the tunica media and intima leading to stenosis/aneurysm.

Fibromuscular dysplasia has ____________ and ___________ of the tunica media and intima leading to stenosis/aneurysm.

• A. Hyperplasia and fibrosis of the tunica adventitia
• B. Hypertrophy and calcification of the tunica media
• C. Hypertrophy and thinning of the tunica intima
• D. Hyperplasia and fibrosis of the tunica media and intima

Answer: (D)

Fibromuscular dysplasia is a non-atherosclerotic, non-inflammatory arteriopathy that causes fibromuscular proliferation within the vessel wall, leading to irregular thickening and luminal narrowing with possible aneurysm formation. The hallmark histology is hyperplasia and fibrosis of the tunica media and intima, which produces the stenotic segments and, in places, aneurysmal dilation. The other patterns described don’t fit this combination of medial and intimal fibrous changes that drive the characteristic beading and segments of narrowed lumen.

Fibromuscular dysplasia is a non-atherosclerotic, non-inflammatory arteriopathy that causes fibromuscular proliferation within the vessel wall, leading to irregular thickening and luminal narrowing with possible aneurysm formation. The hallmark histology is hyperplasia and fibrosis of the tunica media and intima, which produces the stenotic segments and, in places, aneurysmal dilation. The other patterns described don’t fit this combination of medial and intimal fibrous changes that drive the characteristic beading and segments of narrowed lumen.