Cold agglutinin disease is mediated by which immunoglobulin?

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Multiple Choice

Cold agglutinin disease is mediated by which immunoglobulin?

Explanation:
Cold agglutinin disease is driven by IgM autoantibodies that bind red cells at cold temperatures, forming pentamers with high avidity for surface antigens. This binding efficiently activates the classical complement pathway, leading to intravascular hemolysis or C3b-mediated extravascular destruction. IgG mediates warm autoimmune hemolytic anemia, while IgA and IgE are not typical mediators of this RBC-directed autoimmune process.

Cold agglutinin disease is driven by IgM autoantibodies that bind red cells at cold temperatures, forming pentamers with high avidity for surface antigens. This binding efficiently activates the classical complement pathway, leading to intravascular hemolysis or C3b-mediated extravascular destruction. IgG mediates warm autoimmune hemolytic anemia, while IgA and IgE are not typical mediators of this RBC-directed autoimmune process.

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