Classic PAN is what kind of necrosis leading to ischemia/infarction?

Classic PAN is what kind of necrosis leading to ischemia/infarction?

• A. Fat necrosis
• B. Caseous necrosis
• C. Fibrinoid necrosis
• D. Liquefactive necrosis

Answer: (C)

Classic PAN features necrotizing inflammation of medium-sized arteries with fibrinoid necrosis. In this process, immune complexes and fibrin leak into the vessel wall, producing a bright pink, fibrin-like deposition. This weakens and devastates the vessel wall, commonly narrowing or occluding the lumen and causing ischemia and infarction in organs supplied by those arteries. Other necrosis types—fat necrosis, caseous necrosis, or liquefactive necrosis—occur in different settings and are not characteristic of PAN, whereas the fibrinoid pattern is the hallmark here.

Classic PAN features necrotizing inflammation of medium-sized arteries with fibrinoid necrosis. In this process, immune complexes and fibrin leak into the vessel wall, producing a bright pink, fibrin-like deposition. This weakens and devastates the vessel wall, commonly narrowing or occluding the lumen and causing ischemia and infarction in organs supplied by those arteries. Other necrosis types—fat necrosis, caseous necrosis, or liquefactive necrosis—occur in different settings and are not characteristic of PAN, whereas the fibrinoid pattern is the hallmark here.