Classic KS lesions most commonly occur on which region?

Classic KS lesions most commonly occur on which region?

• A. Face
• B. Distal lower extremities
• C. Trunk
• D. Upper extremities

Answer: (B)

Classic Kaposi sarcoma typically presents first and most prominently on the legs, especially the distal lower extremities. In elderly men of Mediterranean or Jewish descent, you’ll often see violaceous patches on the ankles and shins that may progress to plaques or nodules but remain most concentrated in the legs. This leg predilection reflects how the disease tends to involve skin areas with dependent venous/lymphatic dynamics and slower drainage, where vascular proliferation and edema can accumulate. Facial involvement and trunk/upper-extremity lesions are less characteristic early on in classic KS, and facial or widespread trunk disease is more common in other KS settings, such as AIDS-associated KS.

Classic Kaposi sarcoma typically presents first and most prominently on the legs, especially the distal lower extremities. In elderly men of Mediterranean or Jewish descent, you’ll often see violaceous patches on the ankles and shins that may progress to plaques or nodules but remain most concentrated in the legs. This leg predilection reflects how the disease tends to involve skin areas with dependent venous/lymphatic dynamics and slower drainage, where vascular proliferation and edema can accumulate. Facial involvement and trunk/upper-extremity lesions are less characteristic early on in classic KS, and facial or widespread trunk disease is more common in other KS settings, such as AIDS-associated KS.