Acute hemorrhage anemia is associated with reactive reticulocytosis and which other change?

Acute hemorrhage anemia is associated with reactive reticulocytosis and which other change?

• A. Increase in reticulocytes and platelets
• B. Increase in reticulocytes only, platelets unchanged
• C. No change in reticulocytes or platelets
• D. Increase in platelets only, reticulocytes unchanged

Answer: (A)

Acute hemorrhage triggers a brisk erythropoietic response with reactive thrombocytosis. When blood loss causes tissue hypoxia, the kidneys ramp up erythropoietin, driving the bone marrow to release more reticulocytes as part of rapid red cell production. At the same time, the acute stress and inflammatory signals during hemorrhage promote megakaryopoiesis through thrombopoietin and cytokines, leading to a rise in platelets. So you see both an increase in reticulocytes and an increase in platelets, rather than changes in only one cell line or no change at all.

Acute hemorrhage triggers a brisk erythropoietic response with reactive thrombocytosis. When blood loss causes tissue hypoxia, the kidneys ramp up erythropoietin, driving the bone marrow to release more reticulocytes as part of rapid red cell production. At the same time, the acute stress and inflammatory signals during hemorrhage promote megakaryopoiesis through thrombopoietin and cytokines, leading to a rise in platelets. So you see both an increase in reticulocytes and an increase in platelets, rather than changes in only one cell line or no change at all.