A 65-year-old man with multiple red-purple skin plaques or nodules on the feet and no other symptoms is most likely to have:

A 65-year-old man with multiple red-purple skin plaques or nodules on the feet and no other symptoms is most likely to have:

• A. AIDS-associated KS
• B. Endemic KS
• C. Classic KS
• D. Lymphadenopathic KS

Answer: (C)

Classic Kaposi sarcoma is characterized by slow-growing, violaceous skin lesions on the lower extremities of older men, often of Mediterranean or Eastern European descent, with little or no systemic symptoms. The patient’s age and the presentation of multiple red-purple plaques on the feet with no other symptoms fit this pattern, making classic KS the most likely diagnosis. AIDS-associated KS would typically accompany HIV infection and show more rapid progression with mucocutaneous or visceral involvement; endemic KS occurs in Africa and can affect younger individuals with variable aggressiveness; lymphadenopathic KS centers on lymph node involvement and may have less prominent early skin disease.

Classic Kaposi sarcoma is characterized by slow-growing, violaceous skin lesions on the lower extremities of older men, often of Mediterranean or Eastern European descent, with little or no systemic symptoms. The patient’s age and the presentation of multiple red-purple plaques on the feet with no other symptoms fit this pattern, making classic KS the most likely diagnosis. AIDS-associated KS would typically accompany HIV infection and show more rapid progression with mucocutaneous or visceral involvement; endemic KS occurs in Africa and can affect younger individuals with variable aggressiveness; lymphadenopathic KS centers on lymph node involvement and may have less prominent early skin disease.