A 25-year-old HIV-seronegative patient with enlarged lymph nodes is most consistent with which KS variant?

A 25-year-old HIV-seronegative patient with enlarged lymph nodes is most consistent with which KS variant?

• A. Classic KS
• B. Endemic KS
• C. AIDS-associated KS
• D. Lymphadenopathic KS

Answer: (D)

Focused on presentations of Kaposi sarcoma, the form that shows prominent lymph node involvement with little or no skin disease is lymphadenopathic KS. This pattern is most often seen in younger patients from endemic regions and can occur in individuals who are HIV-negative. In this vignette, the patient is HIV-seronegative and has enlarged lymph nodes, which fits the nodal-predominant presentation of lymphadenopathic KS. Other variants rely on different contexts: AIDS-associated KS requires HIV infection; classic KS typically affects older men with skin lesions; endemic KS is common in Africa and can involve nodes but is not defined by an HIV-negative nodal-dominant presentation.

Focused on presentations of Kaposi sarcoma, the form that shows prominent lymph node involvement with little or no skin disease is lymphadenopathic KS. This pattern is most often seen in younger patients from endemic regions and can occur in individuals who are HIV-negative. In this vignette, the patient is HIV-seronegative and has enlarged lymph nodes, which fits the nodal-predominant presentation of lymphadenopathic KS. Other variants rely on different contexts: AIDS-associated KS requires HIV infection; classic KS typically affects older men with skin lesions; endemic KS is common in Africa and can involve nodes but is not defined by an HIV-negative nodal-dominant presentation.